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Typical pain occurs with stimulus to a nerve ending, causing a voltage
rise or "receptor potential", which then initiates another voltage rise further
up the nerve, a so-called "action potential", which travels along the nerve to
the thalamus, which is the brain's pain regulator. As already stated, the parts of this
system in the central nervous system (brain and cord) should be incapable of responding to
pain. Somehow in Central Pain, the entire length pathway becomes capable of responding to
pain and even generating it inappropriately. Central Pain can reduplicate the sensation
of any torture. The discoverer of the pain tract in humans, Dr. Ron Tasker, has said that
in its severest forms Central Pain can be the worst pain known to man. Descriptions from
patients draw a picture of horrific suffering so terrible that society must wage a war
against the outlaw pain. Because pain medications such as derivatives of opium and their
molecular cousins have no effect on Central Pain except sedation, we need new and better
pain medications.
These will almost certainly eventually be medications capable of blocking the transmission of the
pain signal as it crosses the three junctions (synapses) on the path to the brain.
Although more money is spent on pain relief than any other medical problem, basic pain
research is a pauper. Pain neurochemists are as rare as hen's teeth. Because of the
residual view of pain as "an act of God" rather than a disease, the public as
well as their colleagues often ignore or even resent pain researchers.
The history of pain research records the unvarying abuse of the benefactors of mankind,
those who attack pain itself. Imprisonment and even the death penalty awaited many who
sought to cure pain, as if the treatment of pain were a dark art, rather than pain itself
being the enemy. It is difficult to find a greater tragedy than the life of Morton, who
discovered ether. Lawyers, colleagues, and the public harassed and castigated this heroic
individual and his family until he died, broken. Still, when the sum is totaled, Morton
and his like will be ranked with the angels, as it were, for the good they have done
mankind.
The fact that brain science is slowly becoming fashionable offers hope for the pain
patient. The evil which has survived so far into modern times is being exposed to the
light of day. Good people everywhere will demand a change as the torturer is unmasked.
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